2-Anilinonaphthalene-6-sulfonic acid
This sensitive molecule is an indicator of protein folding, conformational changes and other processes after the exposure of the probe to water.
Dibromobimane
4-Trimethylammonium-2,2,6,6-tetramethylpiperidine-1-oxyl iodide
8-Aminopyrene-1,3,6-trisulfonic acid trisodium salt
8-Aminopyrene-1,3,6-trisulfonic acid trisodium salt (often abbreviated as APTS) is a highly water-soluble, anionic fluorescent dye, which is primarily used as a sensitive labeling reagent in carbohydrate and glycoprotein analysis. Due to its high negative charge (as a resultf of it`s three sulfonic acid groups and a reactive primary amine, it is exceptionally well-suited for the derivatization of reducing sugars via reductive amination.
The Key Scientific applications of APTS are
- Carbohydrate Electrophoresis: APTS is the industry standard for labeling glycans, oligosaccharides, and human milk sugars for analysis via Capillary Gel Electrophoresis with Laser-Induced Fluorescence (CGE-LIF). It`s triple-negative charge provides high electrophoretic mobility and excellent separation resolution.
- Glucose Sensing: It serves as a fluorescent reporter in two-component sensing systems (often paired with viologen-type quenchers) for continuous glucose monitoring, where its fluorescence is restored upon glucose binding.
- Biomolecule Labeling: APTS is used to modify various carbonyl-containing biomolecules, including aldehydes and ketones, and to label glycoproteins for detection in complex biological matrices.
- Medical Research: It is utilized in diagnostic assay manufacturing and research involving glycan biomarkers for diseases such as multiple myeloma.
Di(N-succinimidyl) glutarate
Homobifunctional cross-linking reagent; e.g. isolation of insulin receptor
DSG is disuccinimidyl glutarate, a simple homobifunctional crosslinker builded on the amine-reactive N-hydroxysuccinimide (NHS) ester group at both sidws of a 7.7 angstrom spacer arm. It is used for crosslinking the amine moiety of several molecules. DSG is cell membrane-permeable and it is used in ChIP assays to determine DNA-protein binding interactions.
References:
http://europepmc.org/articles/PMC5669458/
https://www.nature.com/articles/srep14086?proof=true
6-Boc-hydrazinonicotinic acid
trifunctional crosslinking reagents based on biotin for analyzing glycopeptide receptor interactions
Out of stock
Piperazic acid
Bromobimane
Substrate for glutathionetransferase and fluorescent labeling reagent for Thiols
References:
http://www.rsc.org/suppdata/c6/ob/c6ob02110g/c6ob02110g1.pdf
Meconic acid
enzyme inhibitor of hepatitis C virus NS5B polymerase
enzyme inhibitor of Catechol-O-Methyl-transferase
https://en.wikipedia.org/wiki/Meconic_acid