PD 151746
A selective non-peptidic calpain inhibitor
A selective non-peptidic calpain inhibitor
inhibits P-glycoprotein
inhibitor of Btk
inhibitor of v-Src, c-Fyn, c-Ab
c-kit activity inhibitor
Selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively). Shows no significant activity against T
RPV1, P2X2/3, CaV2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.