Apoatropine hydrochloride
Out of stock
Bis-ANS Dipotassium salt
4,4′-Dianilino-1,1′-binaphthyl-5,5′-disulfonic acid dipotassium salt (commonly known as Bis-ANS), is a powerful bifunctional fluorescent probe widely utilized in protein biochemistry. Characterized by its high sensitivity and photostability, this hydrophobic dye is essentially non-fluorescent in aqueous solutions but exhibits a dramatic increase in fluorescence intensity upon binding to nonpolar cavities or exposed hydrophobic regions of proteins.
The main applications are:
- Protein Folding & Conformational Studies: Bis-ANS is a standard tool for detecting intermediate folding states (such as “molten globules”) and monitoring structural perturbations.
- Aggregation Inhibition: Beyond its role as a probe, research suggests Bis-ANS possesses chaperone-like activity, effectively suppressing the aggregation of proteins like insulin and alcohol dehydrogenase by blocking solvent-exposed hydrophobic patches.
- Amyloid Research: It is used to characterize soluble Aβ conformations and tau oligomers, providing distinct fluorescent profiles that differentiate them from mature fibrils.
- Protein Quantification: Recent methodologies have utilized Bis-ANS for sensitive protein assays (range 0.28 to >100 μg/mL) that remain robust in the presence of detergents and inhibitors.
Hypoxanthine 3-N-oxide
Pheromon found in fish.
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Chrysanthemumdicarboxylic acid
Out of stock
D-Eritadenine
inhibitor of S-adenosyl-L-homocysteine hydrolase
17-beta-Hydroxy-5-alpha-androst-2-ene
DSA
This molecule is an amine-reactive homobifunctional cross-linker. It rapidly attacks solvent accessible lysine-NH2 groups at neutral or slightly basic pH. DSA can generate additional structural information about protein structure while generally less often used than DSG or DSS.
Triethylenemelamine
ATR kinase inhibitor
a cytotoxic crystalline compound used as an antineoplastic drug