Apoatropine hydrochloride
Out of stock
Bis-ANS Dipotassium salt
4,4′-Dianilino-1,1′-binaphthyl-5,5′-disulfonic acid dipotassium salt (commonly known as Bis-ANS), is a powerful bifunctional fluorescent probe widely utilized in protein biochemistry. Characterized by its high sensitivity and photostability, this hydrophobic dye is essentially non-fluorescent in aqueous solutions but exhibits a dramatic increase in fluorescence intensity upon binding to nonpolar cavities or exposed hydrophobic regions of proteins.
The main applications are:
- Protein Folding & Conformational Studies: Bis-ANS is a standard tool for detecting intermediate folding states (such as “molten globules”) and monitoring structural perturbations.
- Aggregation Inhibition: Beyond its role as a probe, research suggests Bis-ANS possesses chaperone-like activity, effectively suppressing the aggregation of proteins like insulin and alcohol dehydrogenase by blocking solvent-exposed hydrophobic patches.
- Amyloid Research: It is used to characterize soluble Aβ conformations and tau oligomers, providing distinct fluorescent profiles that differentiate them from mature fibrils.
- Protein Quantification: Recent methodologies have utilized Bis-ANS for sensitive protein assays (range 0.28 to >100 μg/mL) that remain robust in the presence of detergents and inhibitors.
Hypoxanthine 3-N-oxide
Chrysanthemumdicarboxylic acid
Chrysanthemumdicarboxylic-acid is a metabolite from pyrethrum and pyrethroid insecticides. It serves as an analytical biomarker in humans and the environment after exposure.
Out of stock
D-Eritadenine
inhibitor of S-adenosyl-L-homocysteine hydrolase
17-beta-Hydroxy-5-alpha-androst-2-ene
DSA
This molecule is an amine-reactive homobifunctional cross-linker. It rapidly attacks solvent accessible lysine-NH2 groups at neutral or slightly basic pH. DSA can generate additional structural information about protein structure while generally less often used than DSG or DSS.
Triethylenemelamine
Triethylenemelamine (abbreviated TEM, also called Tretamine) is a drug used .
This substance is mutagenic, because it is an antineoplastic alkylating agent. The ethylenrings a very reactive and can bind covalently to DNA at three distinct sites. As a result, TEM can cause chormatid aberrations in cell models. It was one of the first compounds used for chemical mutagenesis in laboratory mice, with the impact on mutagenesis.