Showing 2386–2394 of 6477 results

GANT 58

GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 ┬ÁM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiprolifera

tive and antitumor activity in vivo.