Tetramethylrosamine chloride
Useful dye for studying P gp mediated exclusion from multidrug resistant cells. Superior P gp substance compared to the widely used marker rhodamine.
Apoatropine hydrochloride
2,4-Dinitrotoluene-5-sulfonic acid sodium salt
1,2,3,4-Tetrahydro-1,4-methanonaphthalene-2,3-dimethanol
Out of stock
Bis-ANS Dipotassium salt
4,4′-Dianilino-1,1′-binaphthyl-5,5′-disulfonic acid dipotassium salt (commonly known as Bis-ANS), is a powerful bifunctional fluorescent probe widely utilized in protein biochemistry. Characterized by its high sensitivity and photostability, this hydrophobic dye is essentially non-fluorescent in aqueous solutions but exhibits a dramatic increase in fluorescence intensity upon binding to nonpolar cavities or exposed hydrophobic regions of proteins.
The main applications are:
- Protein Folding & Conformational Studies: Bis-ANS is a standard tool for detecting intermediate folding states (such as “molten globules”) and monitoring structural perturbations.
- Aggregation Inhibition: Beyond its role as a probe, research suggests Bis-ANS possesses chaperone-like activity, effectively suppressing the aggregation of proteins like insulin and alcohol dehydrogenase by blocking solvent-exposed hydrophobic patches.
- Amyloid Research: It is used to characterize soluble Aβ conformations and tau oligomers, providing distinct fluorescent profiles that differentiate them from mature fibrils.
- Protein Quantification: Recent methodologies have utilized Bis-ANS for sensitive protein assays (range 0.28 to >100 μg/mL) that remain robust in the presence of detergents and inhibitors.
TEPA
Used as insect chemosterilant; in dyeing. Antineoplastic
2,4-Diamino-5-(formylamino)-6-hydroxypyrimidine
![2-[(2-Chlorophenyl)amino]-benzaldehyde](https://www.synchem.de/wp-content/uploads/2017/05/un187-247x124.png)