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S-HyNic Crosslinker

The S-HyNic (succinimidyl-6-hydrazino-nicotinamide) heterobifunctional crosslinker is fundamental to Chromaling. S-HyNic reacts with primary amines of proteins (amino group of glycine) or amino-modified oligonucleotides or surfaces, introducing a HyNic (6-hydrazinonicotinamide) linker that forms stable covalent conjugates with biomolecules possessing 4FB (4-formylbenzamide) incorporated linkers.

CoA S-HyNic Crosslinker





Di(N-succinimidyl) glutarate

Homobifunctional cross-linking reagent; e.g. isolation of insulin receptor

DSG is disuccinimidyl glutarate, a simple homobifunctional crosslinker builded on the amine-reactive N-hydroxysuccinimide (NHS) ester group at both sidws of a 7.7 angstrom spacer arm. It is used for crosslinking the amine moiety of several molecules. DSG is cell membrane-permeable and it is used in ChIP assays to determine DNA-protein binding interactions.

CoA BC366






This molecule is an amine-reactive homobifunctional cross-linker. It rapidly attacks solvent accessible lysine-NH2 groups at neutral or slightly basic pH. DSA can generate additional structural information about protein structure while generally less often used than DSG or DSS.


CoA BC366de3

DAPpNP from Synchem

p-Nitrophenyl 3-diazopyruvate

The heterobifunctional cross-linking agent p-nitrophenyl 3-diazopyruvate (DAPpNP) is used for the synthesis of photoaffinity probes and photoactivatable cross-linking agents that are nucleophile specific.