Meconic acid
enzyme inhibitor of hepatitis C virus NS5B polymerase
enzyme inhibitor of Catechol-O-Methyl-transferase
https://en.wikipedia.org/wiki/Meconic_acid
Out of stock
Bis-ANS Dipotassium salt
4,4′-Dianilino-1,1′-binaphthyl-5,5′-disulfonic acid dipotassium salt (commonly known as Bis-ANS), is a powerful bifunctional fluorescent probe widely utilized in protein biochemistry. Characterized by its high sensitivity and photostability, this hydrophobic dye is essentially non-fluorescent in aqueous solutions but exhibits a dramatic increase in fluorescence intensity upon binding to nonpolar cavities or exposed hydrophobic regions of proteins.
The main applications are:
- Protein Folding & Conformational Studies: Bis-ANS is a standard tool for detecting intermediate folding states (such as “molten globules”) and monitoring structural perturbations.
- Aggregation Inhibition: Beyond its role as a probe, research suggests Bis-ANS possesses chaperone-like activity, effectively suppressing the aggregation of proteins like insulin and alcohol dehydrogenase by blocking solvent-exposed hydrophobic patches.
- Amyloid Research: It is used to characterize soluble Aβ conformations and tau oligomers, providing distinct fluorescent profiles that differentiate them from mature fibrils.
- Protein Quantification: Recent methodologies have utilized Bis-ANS for sensitive protein assays (range 0.28 to >100 μg/mL) that remain robust in the presence of detergents and inhibitors.
Out of stock
D-Eritadenine
inhibitor of S-adenosyl-L-homocysteine hydrolase
Triethylenemelamine
ATR kinase inhibitor
a cytotoxic crystalline compound used as an antineoplastic drug
Anagrelide Hydrochloride
CAMP phosphodiesterase inhibitor
JAK2 kinase inhibitor
5-Aminolevulinic acid hydrochloride
Out of stock
Ebselen
IDO Inhibitor
Out of stock
XAV939
Tankyrase inhibitor
Out of stock
J-8 hydrochloride
Calmodulin antagonist